MUSCAT, Oman (AP) — A massive explosion and fire rocked a port Saturday in southern Iran purportedly linked to a shipment of a chemical ingredient used to make missile propellant, killing four people and injuring more than 500 others.

The blast at the Shahid Rajaei port happened as Iran and the United States met Saturday in Oman for the third round of negotiations over Tehran's rapidly advancing nuclear program.

While no one in Iran outright suggested that the explosion came from an attack, even Iranian Foreign Minister Abbas Araghchi, who is leading the talks, on Wednesday acknowledged that “our security services are on high alert given past instances of attempted sabotage and assassination operations designed to provoke a legitimate response.”

For hours, authorities in Iran offered no clear explanation for what caused the blast at the port, which is just outside of Bandar Abbas, though they did deny that the explosion had anything to do with the country's oil industry.

However, the port took in a shipment of "sodium perchlorate rocket fuel" in March, the private security firm Ambrey said. The fuel is part of a shipment from China by two vessels to Iran first reported in January by the Financial Times. The fuel was going to be used to replenish Iran's missile stocks, which had been depleted by its direct attacks on Israel during the war with Hamas in the Gaza Strip.

"The fire was reportedly the result of improper handling of a shipment of solid fuel intended for use in Iranian ballistic missiles," Ambrey said.

Ship-tracking data analyzed by The Associated Press put one of the vessels believed to be carrying the chemical in the vicinity in March, as Ambrey said. Iran hasn't acknowledged taking the shipment. The Iranian mission to the United Nations didn't immediately respond to a request for comment on Saturday.

It's unclear why Iran wouldn't have moved the chemicals from the port, particularly after the Beirut port blast in 2020. That explosion, caused by the ignition of hundreds of tons of highly explosive ammonium nitrate, killed more than 200 people and injured more than 6,000 others. However, Israel did target Iranian missile sites where Tehran uses industrial mixers to create solid fuel.

Social media footage of the explosion on Saturday at Shahid Rajaei saw reddish-hued smoke rising from the fire just before the detonation. That suggests a chemical compound being involved in the blast.

Shahid Rajaei has been a target before. A 2020 cyberattack attributed to Israel targeted the port. It came after Israel said that it thwarted a cyberattack targeting its water infrastructure, which it attributed to Iran.

Social media videos showed black billowing smoke after the blast. Others showed glass blown out of buildings kilometers, or miles, away from the epicenter of the explosion. State media footage showed the injured crowding into at least one hospital, with ambulances arriving as medics rushed one person by on a stretcher.

Mehrdad Hasanzadeh, a provincial disaster management official, told Iranian state television that first responders were trying to reach the area while others were attempting to evacuate the site.

Hasanzadeh said that the blast came from containers at Shahid Rajaei port in the city, without elaborating. State television also reported that there had been a building collapse caused by the explosion, though no further details were offered.

The Interior Ministry said that it launched an investigation into the blast.

Shahid Rajaei port in Hormozgan province is about 1,050 kilometers (650 miles) southeast of Iran's capital, Tehran, on the Strait of Hormuz, the narrow mouth of the Persian Gulf through which 20% of all oil traded passes.

In this photo provided by Islamic Republic News Agency, IRNA, a black smoke rises in the sky as vehicles drive on the road after a massive explosion near the southern port city of Bandar Abbas, Iran, Saturday, April 26, 2025. (Mohammad Rasoul Moradi/IRNA via AP)

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In this photo provided by Islamic Republic News Agency, IRNA, a black smoke rises in the sky as vehicles drive on the road after a massive explosion rocked a port near the southern port city of Bandar Abbas, Iran, Saturday, April 26, 2025. (Mohammad Rasoul Moradi/IRNA via AP)

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This is a locator map for Iran with its capital, Tehran. (AP Photo)

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In this photo provided by Islamic Republic News Agency, IRNA, men carry an injured man after a massive explosion near the southern port city of Bandar Abbas, Iran, Saturday, April 26, 2025. (Mohammad Rasoul Moradi/IRNA via AP)

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In this photo provided by Islamic Republic News Agency, IRNA, two men on a motorcycle drive through debris after a massive explosion rocked a port near the southern port city of Bandar Abbas, Iran, Saturday, April 26, 2025. (Mohammad Rasoul Moradi/IRNA via AP)

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In this photo provided by Islamic Republic News Agency, IRNA, men walk through debris after a massive explosion rocked a port near the southern port city of Bandar Abbas, Iran, Saturday, April 26, 2025. (Mohammad Rasoul Moradi/IRNA via AP)

Credit: AP

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Credit: AP